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ea0047oc15 | Spotlight on Neuroendocrine tumours | Theranostics2016

Evaluation of somatostatin, CXCR4 chemokine and endothelin a receptor expression in a large series of paragangliomas

Kaemmerer Daniel , Saenger Joerg , Arsenic Ruza , D'Haese Jan G. , Neumann Jens , Singh Aviral , Baum Richard P. , Schulz Stefan , Lupp Amelie

Background: Paragangliomas are predominantly benign tumors, but in some cases invasive growth and also metastasis is observed. Given the limited number of nonsurgical treatment options, novel target structures for diagnostics and therapy of this tumor entity are urgently needed.Aims: In the present study the expression of the five somatostatin receptor (SSTR) subtypes as well as of the chemokine receptor CXCR4 and of the endothelin receptor A (ETA) was e...

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ea0046p1 | (1) | UKINETS2016

MicroRNAs associated with small bowel neuroendocrine tumours and their metastases

Miller Helen C , Frampton Adam E , Malczewska Anna , Ottaviani Silvia , Stronach Euan A , Flora Rashpal , Kaemmerer Daniel , Schwach Gert , Pfragner Roswitha , Faiz Omar , Kos-Kudla Beata , Hanna George B , Stebbing Justin , Castellano Leandro , Frilling Andrea

Introduction: Novel molecular analytes are needed in small bowel neuroendocrine tumours (SBNETs) to better determine disease aggressiveness and predict treatment response.Aim of the study: To profile the global miRNome of SBNETs, and identify microRNAs (miRNAs) involved in tumour progression for use as potential biomarkers.Material and methods: Two independent miRNA profiling experiments were performed (n=90), including pr...

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Endocrine Abstracts

Evaluation of somatostatin, CXCR4 chemokine and endothelin a receptor expression in a large series of paragangliomas

MicroRNAs associated with small bowel neuroendocrine tumours and their metastases

BiosciAbstracts